Females have traditionally dominated the nursing profession, but in recent years, men have been entering this field. In India, men account for approximately 10-15 percent of the nursing workforce (Indian Nursing Council, 2021). This study sought to assess the level of professional well-being (work environment, self-esteem and psychological distress) among male nurses. A descriptive cross-sectional study design was employed with 100 male nurses from selected hospitals providing data via Google Forms and using the consecutive sampling method. The tools used for the study were: background variables proforma of male nurses, a work environment assessment, a self-esteem scale, and a psychological distress scale. Half of the male nurses reported having a high level of professional well-being (50%), 61 percent said their workplace was healthy, 22 percent had high self-esteem, and less than half had severe distress (45%). The mean and standard deviation of the overall score of professional well-being of male nurses were 155.81±42.59. A statistically significant positive connection was observed between psychological distress and self-esteem (p < 0.001). Among male nurses, background characteristics such as years of experience, type of organisation, field of employment, and work environment were statistically significantly correlated (p <0.05). The study reveals a paradox in male nurses' professional well-being; despite most reporting a healthy workplace and half showing high well-being, significant concerns persist, and demands urgent action to improve working conditions and mental health support to sustain their vital role in healthcare.