With an increased ageing population, it is inevitable for nurses to encounter people living with dementia at the hospital or in the community. However, not much is known in India, especially in the North-Eastern region, about the knowledge and attitudes of nurses on dementia care. This study aims to examine the knowledge and attitudes of dementia care among nurses in Shillong, Meghalaya, North East India. A descriptive cross-sectional study was conducted among a random sample of registered nurses from 12 secondary and tertiary hospitals. To estimate the level of knowledge, the Dementia Knowledge Assessment Scale (DKAS) version 2 was used, and to evaluate attitudes, the Dementia Attitudes Scale (DAS) was used. Percentage, mean, and Pearson’s correlation were used to analyse the data. The study participants were 114 registered nurses between 23 and 48 years of age, with a mean year of experience of 8.5 years. Only one nurse had dementia training. The mean DKAS version 2 score was 27.5/50, and nurses scored the least in the Communication and Behaviour subscale (4.15/12). The mean DAS score was 99.6/140. There was a statistically significant negative correlation between age and experience with DKAS version 2 scores and a positive correlation between qualification and DAS scores. Educational programmes would effectively improve nurses’ knowledge and attitudes on dementia care.